Capital Research & Management Co. (International Investors)11.08The Vanguard Group, Inc.8.45Vanguard Group, Inc. (Subfiler)8.32T. Rowe Price Investment Management, Inc.7.10American Funds Growth Fund of America5.43T Rowe Price Associates, Inc. (13F Subfiler)5.04Fidelity Management & Research Co. LLC4.34Puretech Health LLC4.01Sofinnova Investments, Inc.3.62Fidelity Management Trust Co.3.17Viking Global Investors LP2.97Pentwater Capital Management LP2.79Wellington Management Co. LLP (Wellington Breakout)2.76Pivotal Bioventure Partners Investment Advisor LLC2.68Vanguard Total Stock Market ETF2.66

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